Feeling worried, frustrated, or even embarrassed by Peyronie’s Disease? You’re not alone.

We offer an innovative regenerative therapy without invasive surgery. Our approach combines Collagenase injections with expanded Mesenchymal Stem Cells to both break down the problematic scar tissue and stimulate your body to repair and straighten the penis.

The most advanced and successful treatment available for Peyronie’s Disease... All prepared and administered in our state-of-the-art Labs. 

Collagenase

An enzyme that softens and dissolves the plaque

Expanded Mesenchymal Stem Cells

Healing cells from your own fat or cord tissue

It leverages cutting-edge Regenerative Medicine to address the Root Cause (scar tissue and fibrosis) and helps Rebuild Normal Tissue, all while incorporating the proven plaque-dissolving power of Collagenase. For a patient suffering the pain, curvature, and embarrassment of Peyronie’s, this dual therapy offers a highly promising path to recovery. It stands out among all other treatments – past and present – by providing a comprehensive solution that is effective, minimally invasive, and backed by scientific innovation, truly earning its reputation as the new gold standard in Peyronie’s disease care.

What is Peyronie’s Disease (PD)?

It is an acquired connective tissue disorder of the penis. It is characterized by the development of fibrous scar tissue (plaques) in the penile tunica albuginea – the elastic covering of the erectile chambers. These plaques cause the penis to bend or curve abnormally when erect, often leading to a noticeable deformity. Men with Peyronie’s may experience a shortened penis length, penile curvature, and even erectile dysfunction due to the loss of elasticity in affected areas.

A relatively common condition...

With studies estimating a prevalence of roughly 3 - 9% among adult men (particularly those in midlife and older), though many cases likely go unreported due to embarrassment or misperception.

How Does Peyronie’s Disease Manifest?

Peyronie’s disease typically develops gradually and can present with a range of symptoms:

  • Penile Curvature: The most frequent sign is a curvature of the erect penis, which can be upward, downward, or to the side, depending on plaque location. Some men also notice indentations or an “hourglass” narrowing of the shaft.
  • Palpable Plaque: Many patients can feel hard lumps or bands under the skin of the penis (the scar tissue). These plaques are often on the dorsal (top) side but can occur elsewhere.
  • Pain: During the initial (acute) phase of PD, there may be pain in the penis, especially during erections. This pain often subsides as the condition enters a chronic phase, even if the curvature remains.
  • Erectile Dysfunction: Due to the deformity and the fibrosis in the penile tissue, erectile dysfunction (ED) occurs in an estimated 30–70% of men with Peyronie’s. ED may result from impaired blood flow or psychological distress related to the condition.
  • Difficulty with Intercourse: The curvature and associated pain or rigidity issues can make sexual intercourse difficult or impossible, depending on severity. Men often report trouble with penetration and changes in sexual performance.

These symptoms can appear or worsen over a period of months. Peyronie’s disease often has an acute inflammatory phase (lasting 6 - 18 months) where curvature may worsen, followed by a chronic phase where the condition stabilizes (curvature stops progressing, pain usually decreases). However, without treatment, the curvature and plaque typically persist into the chronic phase.

Consequences and Impact of Peyronie’s Disease

Because of its impact on sexual function and self-image, PD can have profound consequences on a man’s quality of life:

Sexual Dysfunction

The fibrous plaque makes the affected portion of the penis inelastic, which can impede normal erections and sexual activity. Men may not be able to engage in intercourse if the bend is severe or if pain and ED are present.

Psychological Distress

Psychological Distress: Peyronie’s often causes significant emotional and psychological distress. The disfigurement and sexual difficulties can lead to anxiety, lowered self-esteem, and depression.

Relationship Strain

The combination of physical limitations and emotional stress can put a strain on intimate relationships. Communication issues or reduced sexual frequency may occur, sometimes causing tension between partners.

Progression to Erectile Dysfunction

If not addressed, the condition can worsen. The chronic scar tissue may cause worsening erectile function over time, partly due to poor blood flow in the area of the plaque and the mechanical hindrance of the scar.

Conventional Treatments and their Limitations:

Because of its impact on sexual function and self-image, PD can have profound consequences on a man’s quality of life:

Oral Medications AND TOPICALS

Pills (vitamin E, Potaba, tamoxifen, etc.) and creams have been tried, but no oral drug has shown definitive improvement in curvature.

Intralesional Injections

Doctors have injected substances like interferon-alpha-2b directly into plaques in an attempt to soften them. However, rigorous trials failed to show significant improvements in penile deformity or plaque size for these agents. Steroid injections have also been used, but with little objective benefit and potential tissue-thinning side effects.

Collagenase Injections

It’s the first FDA-approved medication for Peyronie’s Disease and is injected into the plaque to break down scar tissue. Collagenase treatment has shown moderate success - studies report an average improvement of about 30% in curvature. However, collagenase is not a perfect cure: multiple treatment cycles are needed, and some men still require additional interventions.

Mechanical Therapies

Penile traction devices and vacuum erection devices are sometimes used, in combination with other treatments and can help improve curvature and restore some length, especially when combined with surgery.

SURGERY

For severe cases surgery has been the traditional gold-standard treatment. Surgical options include plaque incision or excision with grafting or penile plication. Surgery can effectively straighten the penis, but it is invasive and not without complications. Common drawbacks are penile shortening (especially with plication procedures) and the risk of worsening erectile dysfunction due to neurovascular damage or altered hemodynamics.

Can’t wait to feel like yourself again?

How?

It’s easier than you think. Discover the world’s most advanced Stem Cell and Exosomes treatment. Reach out to us — we’re here for you and happy to answer any questions you may have.

Where?

Help Desk +390549909905
Help Desk info@bioinst.com

Como (Italy)
Milano (Italy)
Rome (Italy)
Varese (Italy)
Falciano (RSM)

MSCs + CCH the Gold Standard for Peyronie’s

For patients suffering from Peyronie’s disease the combined mesenchymal stem cell and collagenase treatment represents a state-of-the-art solution. Here’s why this therapy is considered by many experts as a “gold standard”approach moving forward:

  • Superior Efficacy: By attacking the problem on two fronts, this therapy yields greater improvements in penile curvature and plaque resolution than traditional treatments. Collagenase alone improves curvature modestly (often around one-third reduction), but adding MSCs can further enhance straightening and even help eliminate plaques in some cases.
  • Tissue Restoration, Not Just Symptom Relief: Unlike approaches that simply reduce the bend or deal with symptoms, stem cell therapy actively heals the damaged tissue. The MSCs encourage the growth of healthy, flexible tissue in place of rigid scar.
  • Prevention of Future Complications: One of the most feared outcomes of Peyronie’s is progressive ED and penile shortening. The anti-fibrotic action of MSCs can halt the disease’s progression and help preserve penile length and elasticity by preventing further scar buildup.
  • Minimally Invasive & Safe: The combined therapy is delivered via injections – a far less invasive route than open surgery. Expanded MSCs (expanded in Bioscience Institute lab) are injected directly into the plaque or penile tissue, typically in an outpatient setting. Collagenase injections are also quite safe – serious complications are uncommon and largely avoidable with proper technique.
  • Enhanced Quality of Life:  By significantly straightening the penis and improving erections, the stem cell + collagenase therapy can make sexual intercourse possible again without pain or difficulty. The positive impact on intimacy and self-esteem is life-changing.
Stem Cell Procedure

Let’s clarify with accurate information:

Stem Cells obtained from a fat sample require at least two weeks of processing before they can be used; otherwise, the treatment is ineffective and potentially harmful:

  • Fat that is harvested and manipulated for use in the same session is both useless and harmful.
  • There are no Stem Cells in the blood, so treatments claiming to use stem cells extracted from blood are not scientifically valid. The Stem Cells used to treat hematological diseases are found in the bone marrow, not in the blood.
  • The hematopoietic stem cells found in umbilical cord blood are useful for treating blood disorders, but not for counteracting the aging processes of the human body

Contact us Today

Why?

Because you deserve to feel great again. To feel like yourself. The solution exists — it’s real, and it starts with your choice.

Where?

Help Desk +390549909905
Help Desk info@bioinst.com

Como (Italy)
Milano (Italy)
Rome (Italy)
Varese (Italy)
Falciano (RSM)

The cutting-edge Treatment: Mesenchymal Stem Cells + Collagenase

One of the most advanced therapeutic solutions for Peyronie’s disease today harnesses the power of regenerative medicine by using expanded Mesenchymal Stem Cells (MSCs) in combination with Collagenase injections. This combination therapy is at the forefront of Peyronie’s treatment, aiming to maximize plaque reduction and promote healing better than any single therapy available on the market.

The Role of Mesenchymal Stem Cells (MSCs):

Mesenchymal stem cells are a type of adult stem cell found in various tissues (like adipose fat or cord tissue). They have the remarkable ability to self-renew and differentiate into multiple cell types, including those involved in tissue repair. Importantly for Peyronie’s, MSCs also have powerful anti-fibrotic, anti-inflammatory, and immunomodulatory properties. In other words, they can secrete growth factors and cytokines that reduce scarring, break down excess collagen, and encourage healthy tissue regeneration in the affected area. MSC therapy decrease penile curvature and plaque size by counteracting the fibrosis process. Injecting placental-derived MSCs into Peyronie’s plaques resulted in 7 out of 10 treated plaques completely disappearing at 3 months, with significant improvements in penile blood flow. Such findings underscore the potent regenerative effect that stem cells can exert on scarred penile tissue.

The Stem Cell Source

Mesenchymal stem cells are the same regardless of whether they are derived from Adipose Tissue or Umbilical Cord Tissue. The only difference lies in their biological age, which reflects the age of the tissue of origin.

Adipose Tissue Derived Stem Cells 

The treatment requires a fat collection, stem cell extraction, and expansion. The entire process takes approximately 2–3 weeks. Therefore, from the moment of fat harvesting, a waiting period of 2–3 weeks is necessary before the treatment can be performed.

Umbilical Cord Tissue derived Stem Cells

The treatment does not require fat harvesting and can be performed within 2–3 days of the request.

The Role of Collagenase (CCH)

Collagenase Clostridium Histolyticum (CCH) is an enzyme that specifically digests the collagen fibers constituting Peyronie’s plaques. By injecting CCH into the plaque, we effectively “weaken” or partially dissolve the scar tissue. This enzymatic treatment has been proven to reduce curvature and plaque firmness (about 30% on average curvature improvement with standard protocols). Collagenase essentially provides a mechanical benefit: it breaks up the problematic collagen bundles within the plaque, making the penis straighter and the plaque softer. It’s a highly targeted way to attack the structure of the scar.

Synergistic Effect of MSCs + Collagenase

A medical consultation is first performed to assess whether the patient is a suitable candidate for stem cell therapy. This evaluation ensures that the underlying causes of the patient’s erectile dysfunction fall within those that can be successfully treated with stem cell-based therapy. The treatment consists of a localized injection of stem cells, which may be repeated over time depending on the results achieved. When deemed appropriate, the localized injection may be combined with systemic administration of stem cells to support overall physiological balance and enhance the effectiveness of the localized treatment. The localized injection is intended to directly address erectile dysfunction, while the systemic infusion aims to improve general health conditions. The treatment may also be combined with other therapeutic procedures, if considered beneficial by the physician.

Learn how Stem Cells and Exosomes can change your life!

When?

Today! Reach out to us with confidence and discover the world’s most innovative solutions for Erectile Dysfunction. Our experts are here for you — ready to provide all the information and support you need to feel like yourself again.

Where?

Help Desk +390549909905
Help Desk info@bioinst.com

Como (Italy)
Milano (Italy)
Rome (Italy)
Varese (Italy)
Falciano (RSM)

Stromal Vascular Fraction (SVF) VS Mesenchymal Stem Cells (MSC)

In the regenerative medicine landscape, many providers offer therapies labeled as "Stem Cell treatments" that utilize Stromal Vascular Fraction (SVF)—a heterogeneous mix of cells extracted from adipose tissue. While SVF contains some Stem Cells, it also includes various other cell types, leading to variability in treatment outcomes.
At our Clinic, we prioritize precision and efficacy by exclusively using Mesenchymal Stem Cells (MSCs). These are meticulously isolated and expanded in controlled laboratory settings, ensuring a pure, potent, and standardized cell population. This approach enhances the therapeutic potential and consistency of our treatments.

Standard Product and Therapy

MSC
YES, A pharma-grade product derived from a cell isolation and culture process, subject to strict quality control procedures

SVF
NO, Composition varies based on the collection site, the patient’s biological age, the digestion technique used, and several other factors.

Cellular Homogeneity

MSC
YES, Isolated and phenotyped cells

SVF
NO, Heterogeneous cell population

Concentration of MSC

MSC
100%

SVF
Between 0,001% and 0,01% of the total cells within

MSC per 10ml FAT

MSC
>100.000.000 after expansion

SVF
Around 9.000

Microphages per 10ml FAT

MSC
0 - Eliminated through isolation of MSCs

SVF
>400.000

Side Effects

MSC
NO

SVF
YES, often unpredictable, usually mediated by inflammatory processes caused by the macrophage population or potential bacterial contamination

Dosage

MSC
VARIOUS DOSAGES AVAILABLE
10-200 millions of MSC (based on indications)

SVF
SINGLE DOSAGE
not tailored to treatment

Safety

MSC
Pharma-grade production process, subjected to quality controls that ensure product sterility and biological safety

SVF
The production process is not monitorable and not subject to quality and biological safety controls

Treatments from 1 fat Collection

MSC
≥10

SVF
1

Phenotyping

MSC
YES

SVF
NO

Cellular Composition

MSC
Mesenchymal Stem Cells

SVF
Pericytes, Macrophages, Endothelial Cells, Mesenchymal Stem Cells, Adipocytes, Lymphocytes, Fibroblasts

Quality Control

MSC
Endotoxins, Mycoplasma, Anaerobic/Aerobic Bacteria, Viruses, Phenotype

SVF
None

Production Time

MSC
2-4 Weeks

SVF
1 hour

FDA Approval

MSC
YES (Ryoncil 18-12-2024)

SVF
NO

EMA Approval

MSC
YES (Alofisel, Spherox, Ryoncil)

SVF
NO

Usage

MSC
Autologous and Allogenic Localized and Systemic

SVF
Strictly Autologous, Homologous, and Localized

    POWERED BY

    BioScience Institute

    As the world’s leading center of Stem Cell and Regenerative Medicine, Bioscience offers unparalleled service and treatments, unique only to it. Bioscience offers the most advanced personalized expanded adipose derived Stem Cell therapies across Europe – including Rome, Milan, and San Marino, and the Middle East, including Dubai.

    The team at Bioscience Institute does not believe in using invasive surgeries when they can be partially replaced by cell biology. Therefore, they have designed an alternative method of extracting stem cells from adipose tissue. As a distinctive and versatile offering, adipose tissue provides an effective solution to all of Bioscience regenerative services, ranging from to hair loss treatments, to skin aging, to body reshaping treatments.

    Bioscience Institute Vision

    The beauty of regenerative medicine therapies and Stem Cell treatments comes from the ability to use your own body to help heal and enhance your well-being through living body tissue. Bioscience Institute’s vision is based on using this most effective and advanced Stem Cell treatments that is based on cell biology and Exosomes to help amplify our natural healing process in the areas it is needed most or take over the function of damaged tissue altogether.

    Stem cells verified treatments

    With the ability to develop methods to regrow, repair, or replace damaged cells and tissues, using Stem Cell & regenerative medicines provides a natural method of treatment that is less traumatic to the body and more effective than other more invasive treatments and surgeries. The stem cell therapies provided by Bioscience Institute are verified in Europe and the Middle East by scientific evidence of increased safety and efficiency than any other treatment method.

    Scientific Research

    The Bioscience’s profits are consistently reinvested into developing research. Avoiding a flashy commercial profile allows us to concentrate on using investments to create better treatments and ultimately help clients globally. Due to this commitment, Bioscience Institute has instigated important scientific collaborations with leading universities, pioneering procedures and methods around cell products.

    Bioscience Cell Factory and Clinic in Dubai, San Marino, Italy & Switzerland

    Bioscience Institute is the first and only GMP-certified Clinic in the Middle East and Europe, offering stem cell treatments with the most advanced personalized autologous cell therapies worldwide.
    Offering a unique service and treatment sets it apart from any form of competition and allows it to give clients the care, attention, and treatment they deserve.

    • Bioscience Clinics in the Middle East and Europe include a fully equipped facility needed to carry out any treatments offered, whether Stem Cell treatments or banking.
    • Bioscience Laboratory is a dedicated Cell Banking Factory used to store and expand Adipose-Derived Cells and Fibroblasts to help ensure that the clients’ needs can always and easily be catered to.