Struggling with raised, stubborn scars? Learn about cutting-edge treatments backed by Science.
How do Keloids Form?
Keloids are the result of an abnormal wound healing process driven by an exaggerated immune response. When the skin is injured, the body naturally triggers inflammation to initiate tissue repair. However, in some individuals, this immune-mediated inflammatory response becomes excessive and prolonged. This chronic inflammation stimulates fibroblasts to overproduce collagen and extracellular matrix components beyond what is needed for normal healing. As a result, a dense, raised scar—known as a keloid—develops, often extending beyond the boundaries of the original injury. Keloid formation is therefore not simply a matter of scarring, but a dysregulated immune and inflammatory process that leads to pathological tissue remodeling.
Mesenchymal Stem Cells: The Most Effective Treatment for Keloids
Unlike conventional treatments that focus on removing the keloid or suppressing symptoms, Mesenchymal Stem Cells (MSCs) target the root cause of keloid formation: an abnormal immune response, chronic inflammation, and uncontrolled fibrosis.
MSCs are naturally immunomodulatory, meaning they regulate the immune system to prevent excessive or prolonged inflammatory reactions. They also possess strong anti-inflammatory and anti-fibrotic properties, which allow them to:
Calm the chronic inflammation that drives abnormal Scar formation
Inhibit the overactivation of Fibroblasts and excessive Collagen production
Restore balance to the wound-healing process
As a result, MSCs help reprogram the local tissue environment, preventing the recurrence of keloids and promoting healthy tissue regeneration instead of pathological scarring. Moreover, MSC-based therapies are completely non-invasive, usually administered through topical application or microinjections, and they do not damage the skin. They are biocompatible, with no side effects, and are safe for repeated use—even in sensitive or previously treated areas.
This makes MSCs the only truly effective and side-effect-free solution for managing keloids, particularly in patients where conventional treatments have failed or led to recurrence.
Untreated section of the Keloid
Section treated with Stem Cells
Section treated with Surgery
Why do Keloids return after removal?
Because keloids are driven by an underlying inflammatory and immune dysregulation, simply removing them surgically or with laser does not address the root cause. In fact, the act of removing the keloid creates a new injury to the skin, which can trigger the same inflammatory cascade - leading the body to form an identical keloid in the same area, often with the same or even greater volume and thickness. This is why recurrence after surgical or laser removal is very common, unless the immune-inflammatory response is properly modulated or suppressed during the healing process.
SURGICAL EXCISION
Surgical removal of a keloid may seem like a straightforward solution, but in most cases, it is ineffective—and often counterproductive.
The act of excising a keloid creates a new skin injury: in individuals prone to keloid formation, the immune system reacts to injury with an exaggerated and prolonged inflammatory process. This leads to the formation of a new keloid scar—often as large or even larger than the original. Without addressing the underlying immune dysregulation and inflammation, surgical excision alone almost inevitably leads to recurrence.
Surgery is generally discouraged as a standalone treatment and is only considered when combined with adjuvant therapies (such as corticosteroid injections, silicone therapy, or radiation) aimed at modulating the wound healing response.
LASER ABLATION
Laser ablation—or resurfacing—may be effective for many types of scars, but it is generally ineffective for keloids. This is because keloids are not just superficial skin irregularities: they are the result of a deep, chronic inflammatory and immune-mediated process that affects the dermis and even subdermal layers.
When a laser is used to abrade or remove a keloid, it creates micro-injuries in the skin. In individuals prone to keloid formation, even these small injuries can reactivate the pathological wound-healing process—triggering excessive collagen production and leading to the formation of a new keloid, often identical or even worse than the original.
Without suppressing or modulating this underlying mechanism, laser treatment alone will not prevent recurrence—and in fact, may promote it.
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The Stem Cell Source
Mesenchymal stem cells are the same regardless of whether they are derived from Adipose Tissue or Umbilical Cord Tissue. The only difference lies in their biological age, which reflects the age of the tissue of origin.
Adipose Tissue Derived Stem Cells
Umbilical Cord Tissue derived Stem Cells
The treatment does not require fat harvesting and can be performed within 2–3 days of the request.
Let’s clarify with accurate information:
Stem Cells obtained from a fat sample require at least two weeks of processing before they can be used; otherwise, the treatment is ineffective and potentially harmful:
- Fat that is harvested and manipulated for use in the same session is both useless and harmful.
- There are no Stem Cells in the blood, so treatments claiming to use stem cells extracted from blood are not scientifically valid. The Stem Cells used to treat hematological diseases are found in the bone marrow, not in the blood.
- The hematopoietic stem cells found in umbilical cord blood are useful for treating blood disorders, but not for counteracting the aging processes of the human body
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Why?
Because you deserve to feel young, beautiful, and self confident again. The solution exists — it’s real, and it starts with your choice.
Where?
Como (Italy)
Milano (Italy)
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Falciano (RSM)
What to Expect from Mesenchymal Stem Cell (MSC) Treatment for Keloids Removal
Expanded MSC therapy—administered via injection or applied topically in controlled conditions—has consistently shown scar regression, improved tissue structure, and excellent safety in preclinical studies and early human trials. It represents the most promising, mechanism-driven approaches for keloid treatment.
MACROSCOPIC IMPROVEMENT
MSC significantly reduced scar thickness and pale appearance, yielding smoother, flattened, and more visually acceptable scars with no reported adverse events.
Histological & Tissue-Level Benefits
Histologically, treated scars show reduced collagen density and alignment, fewer myofibroblasts, and lowered expression of fibrotic markers such as αSMA and type I collagen.
MSC-derived exosomes reduced fibrosis by modulating oxidative stress, and balanced collagen types I and III in scar tissue.
Anti-Inflammatory and Immunomodulatory Effects
MSCs shift macrophages from a pro-inflammatory M1 phenotype to anti-inflammatory M2, calming the excessive inflammatory response at the core of keloid pathogenesis.
Conditioned media from human adipose-derived MSCs suppressed fibrotic gene expression, reduced fibroblast proliferation and migration, and diminished
angiogenesis in explant models.
Expected Result
Scar Appearance
Thinning, flattening, normalization of texture or color.Tissue Composition
Less disorganized collagen, fewer myofibroblasts.Inflammation
Reduced chronic inflammation via macrophage modulation.Side Effects
None reported in current research.
Learn how Stem Cells and Exosomes can change your life!
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Stromal Vascular Fraction (SVF) VS Mesenchymal Stem Cells (MSC)
At our Clinic, we prioritize precision and efficacy by exclusively using Mesenchymal Stem Cells (MSCs). These are meticulously isolated and expanded in controlled laboratory settings, ensuring a pure, potent, and standardized cell population. This approach enhances the therapeutic potential and consistency of our treatments.
POWERED BY
As the world’s leading center of Stem Cell and Regenerative Medicine, Bioscience offers unparalleled service and treatments, unique only to it. Bioscience offers the most advanced personalized expanded adipose derived Stem Cell therapies across Europe – including Rome, Milan, and San Marino, and the Middle East, including Dubai.
The team at Bioscience Institute does not believe in using invasive surgeries when they can be partially replaced by cell biology. Therefore, they have designed an alternative method of extracting stem cells from adipose tissue. As a distinctive and versatile offering, adipose tissue provides an effective solution to all of Bioscience regenerative services, ranging from to hair loss treatments, to skin aging, to body reshaping treatments.
Bioscience Institute Vision
The beauty of regenerative medicine therapies and Stem Cell treatments comes from the ability to use your own body to help heal and enhance your well-being through living body tissue. Bioscience Institute’s vision is based on using this most effective and advanced Stem Cell treatments that is based on cell biology and Exosomes to help amplify our natural healing process in the areas it is needed most or take over the function of damaged tissue altogether.
Stem cells verified treatments
With the ability to develop methods to regrow, repair, or replace damaged cells and tissues, using Stem Cell & regenerative medicines provides a natural method of treatment that is less traumatic to the body and more effective than other more invasive treatments and surgeries. The stem cell therapies provided by Bioscience Institute are verified in Europe and the Middle East by scientific evidence of increased safety and efficiency than any other treatment method.
Scientific Research
The Bioscience’s profits are consistently reinvested into developing research. Avoiding a flashy commercial profile allows us to concentrate on using investments to create better treatments and ultimately help clients globally. Due to this commitment, Bioscience Institute has instigated important scientific collaborations with leading universities, pioneering procedures and methods around cell products.
Bioscience Cell Factory and Clinic in Dubai, San Marino, Italy & Switzerland
Bioscience Institute is the first and only GMP-certified Clinic in the Middle East and Europe, offering stem cell treatments with the most advanced personalized autologous cell therapies worldwide.
Offering a unique service and treatment sets it apart from any form of competition and allows it to give clients the care, attention, and treatment they deserve.
- Bioscience Clinics in the Middle East and Europe include a fully equipped facility needed to carry out any treatments offered, whether Stem Cell treatments or banking.
- Bioscience Laboratory is a dedicated Cell Banking Factory used to store and expand Adipose-Derived Cells and Fibroblasts to help ensure that the clients’ needs can always and easily be catered to.